An Explainable Deep Transfer Learning Approach with Augmentation for Chest X-Ray-Driven Pulmonary Disease Diagnosis

Authors

  • R. Sriramkumar, M.Tech Department of Information Technology, Annamalai University, Chidambaram, India https://orcid.org/0009-0004-7794-0081
  • K. Selvakumar, PhD Department of Information Technology, Annamalai University, Chidambaram, India
  • J. Jegan, PhD Department of Computer Science and Engineering, SRM Institute of Science and Technology, Tiruchirappalli, Tamil Nadu, India

DOI:

https://doi.org/10.30953/thmt.v10.594

Keywords:

Chest X-ray, clinical decision support, ConvNeXt, deep transfer learning, EfficientNetV2, ensemble learning, pulmonary disease detection, Swin Transformer

Abstract

Chest X-ray imaging plays a vital role in the evaluation of thoracic organs, serving as a primary diagnostic tool for various pulmonary conditions. Interpretations of chest X-ray reports can sometimes differ from a physician’s clinical judgment, leading to diagnostic inconsistencies and potential delays in treatment. This study explores whether the application of advanced deep transfer learning techniques can improve the accuracy of chest X-ray interpretation. Deep Learning presents powerful capabilities for processing and interpreting complex imaging data. Convolutional Neural Networks (CNNs) are widely used in deep learning to perform image classification through hierarchical feature extraction. training deep models with large annotated datasets often demands significant computational resources. In this research, MobileNet and Inception V3 architectures are employed to detect diseases such as lung cancer, pneumonia, and tuberculosis from chest X-ray images. Conducted a detailed evaluation of these models and compare their performance with traditional diagnostic approaches. The results demonstrate notable improvements in accuracy and sensitivity, confirming that deep transfer learning techniques significantly enhance diagnostic outcomes. This suggests that MobileNet and Inception V3 can serve as reliable, efficient tools to support radiologists in early detection and decision-making, and contributing to more timely and accurate medical diagnoses.

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References

Mahamud E, Fahad N, Assaduzzaman M, Zain SM, Goh KO, Morol MK. An explainable artificial intelligence model for multiple lung diseases classification from chest X-ray images using fine-tuned transfer learning. Dec Anal J. 2024;12:100499. https://doi.org/10.1016/j.dajour.2024.100499

Agughasi VI. Leveraging transfer learning for efficient diagnosis of COPD using CXR images and explainable AI techniques. Intel Artif. 2024;27(74):133–51. https://doi.org/10.4114/intartif.vol27iss74pp133-151

Marvin G, Alam MG. Explainable augmented intelligence and deep transfer learning for pediatric pulmonary health evaluation. In: 2022 International Conference on Innovations in Science, Engineering and Technology (ICISET); 2022 Feb 26 (pp. 272–7). IEEE.

Sufian MA, Hamzi W, Sharifi T, Zaman S, Alsadder L, Lee E, et al. AI-driven thoracic X-ray diagnostics: transformative transfer learning for clinical validation in pulmonary radiography. J Pers Med. 2024;14(8):856. https://doi.org/10.3390/jpm14080856

Sarp S, Catak FO, Kuzlu M, Cali U, Kusetogullari H, Zhao Y, et al. An XAI approach for COVID-19 detection using transfer learning with X-ray images. Heliyon. 2023;9(4):e15137. https://doi.org/10.1016/j.heliyon.2023.e15137

Sriramkumar R, Selvakumar K, Jegan J. Advances in AI for pulmonary disease diagnosis using lung X-ray scan and chest multi-slice CT scan. J Theor Appl Inform Technol. 2025; 103(7):2763–72.

Agughasi VI. xAI: an explainable AI model for the diagnosis of COPD from CXR images. IEEE; 2023. https://doi.org/10.1109/ICDDS59137.2023.10434619

Shah ST, Shah SA, Khan II, Imran A, Shah SB, Mehmood A, et al. Data-driven classification and explainable-AI in the field of lung imaging. Front Big Data. 2024;7:1393758. https://doi.org/10.3389/fdata.2024.1393758

Lakshmanan M, Sriramkumar R, Justindhas Y, Ilamurugan G. Blockchain-based HSFO framework for privacy preservation of health care data using hybrid algorithms. In: 2025 2nd International Conference on Research Methodologies in Knowledge Management, Artificial Intelligence and Telecommunication Engineering (RMKMATE); 2025 May 7 (pp. 1–6). IEEE.

Fu X, Lin R, Du W, Tavares A, Liang Y. Explainable hybrid transformer for multi-classification of lung disease using chest X-rays. Sci Rep. 2025;15(1):6650. https://doi.org/10.1038/s41598-025-90607-x

Ashtagi R, Khanapurkar N, Patil AR, Sarmalkar V, Chaugule B, Naveen HM. Enhancing pneumonia diagnosis with transfer learning: a deep learning approach. Inform Dynam Appl. 2024;3(2):104–24. https://doi.org/10.56578/ida030203

Alammar Z, Alzubaidi L, Zhang J, Li Y, Lafta W, Gu Y. Deep transfer learning with enhanced feature fusion for detection of abnormalities in x-ray images. Cancers. 2023;15(15):4007. https://doi.org/10.3390/cancers15154007

Suriyamoorthy A, Shroff S, Baskaran CV, Bhadwal S. Telemedicine in urology practice in India during the COVID-19 pandemic. Telehealth Med Today. 2025;10(2):580. https://doi.org/10.30953/thmt.v10.580

Nguyen NA, Holderread B, Lee G, Reddy D, Schwartz R. Integrating image-based artificial intelligence in the operating room: enhancing safety and efficiency while navigating ethical considerations. Telehealth Med Today. 2025;10(2):578. https://doi.org/10.30953/thmt.v10.578

Lakshmanan M, Dhanraj JA, Sriramkumar R, Naik MN, Mithaguru K. Blockchain-enabled medical waste management system for enhanced traceability, safety and environmental protection. Int J Adv Soft Comput Appl. 2025;17(3):1–15. https://doi.org/10.15849/IJASCA.250730.13

Sharma N, Saba L, Khanna NN, Kalra MK, Fouda MM, Suri JS. Segmentation-based classification deep learning model embedded with explainable AI for COVID-19 detection in chest X-ray scans. Diagnostics. 2022;12(9):2132. https://doi.org/10.3390/diagnostics12092132

Koul A, Bawa RK, Kumar Y. Enhancing the detection of airway disease by applying deep learning and explainable artificial intelligence. Multim Tools Appl. 2024;83(31):76773–805. https://doi.org/10.1007/s11042-024-18381-y

Sarker S, Refat SR, Preotee FF, Shawon TR, Tanvir R. Comprehensive lung disease detection using deep learning models and hybrid chest X-ray data with explainable AI. In: 2024 27th International Conference on Computer and Information Technology (ICCIT); 2024 Dec 20 (pp. 2279–84). IEEE.

Hole SR, Kolluru V, Salotagi S, Challagundla Y, Mungara S. A design of hybrid model and Bayesian neural networks for smart grid stability prediction. In: 2025 IEEE 1st International Conference on Smart and Sustainable Developments in Electrical Engineering (SSDEE); 2025 Feb 28 (pp. 1–7). IEEE.

Lakshmanan M, Mala GA, Poorni R, Ilamurugan G, Sriramkumar R, Gnanavel R. Blockchain for secure and efficient crowdfunding: an optimized particle swarm approach. In: 2024 9th International Conference on Communication and Electronics Systems (ICCES); 2024 Dec 16 (pp. 848–54). IEEE.

Priyatharsini GS, Sivaneasan S, Kshirsagar PR, Chakrabarti P. Revolutionizing lung disease diagnosis: a unique hybrid deep learning framework for explainable chest X-ray analysis. SSRN 5110794.

Perla S, Veledendi S, Jaiswal P, Muppidi S, Mandala J, Maram B. Transfer learning based analysis of chest X-rays for accurate lung disease detection and interpretation. In: 2025 International Conference on Intelligent and Innovative Technologies in Computing, Electrical and Electronics (IITCEE); 2025 Jan 16 (pp. 1–8). IEEE.

Vidal PL, de Moura J, Novo J, Ortega M. Multi-stage transfer learning for lung segmentation using portable X-ray devices for patients with COVID-19. Exp Syst Appl. 2021;173:114677. https://doi.org/10.1016/j.eswa.2021.114677

Sriramkumar R, Selvakumar K, Jegan J. Hybrid vision transformer and CNN framework for multi-disease pulmonary diagnosis. In: 2025 9th International Conference on Inventive Systems and Control (ICISC); 2025 Aug 12 (pp. 769–74). IEEE.

Alshanketi F, Alharbi A, Kuruvilla M, Mahzoon V, Siddiqui ST, Rana N, et al. Pneumonia detection from chest x-ray images using deep learning and transfer learning for imbalanced datasets. J Imaging Inform Med. 2025;38(4):2021–40. https://doi.org/10.1007/s10278-024-01334-0

Choudhry IA, Iqbal S, Alhussein M, Qureshi AN, Aurangzeb K, Naqvi RA. Transforming lung disease diagnosis with transfer learning using chest X-ray images on cloud computing. Exp Syst. 2025;42(2):e13750. https://doi.org/10.1111/exsy.13750

Sriramkumar R, Selvakumar K, Jegan J. An Explainable Deep Transfer Learning Approach with Augmentation for Chest X-Ray-Driven Pulmonary Disease Diagnosis. Telehealth and Medicine Today. 2025;10:594. https://doi.org/10.30953/thmt.v10.594.

Published

2025-12-19

How to Cite

Sriramkumar, R., Selvakumar, PhD, K. ., & Jegan, PhD, J. . (2025). An Explainable Deep Transfer Learning Approach with Augmentation for Chest X-Ray-Driven Pulmonary Disease Diagnosis. Telehealth and Medicine Today, 10(4). https://doi.org/10.30953/thmt.v10.594

Issue

Section

Original Clinical Research