Early Prediction of Preeclampsia by Using Ensemble Machine Learning With MM-XAI Approach
DOI:
https://doi.org/10.30953/thmt.v11.663Keywords:
ensemble of machine learning, LIME, multi-method XAI, preeclampsia, SHAPAbstract
Preeclampsia is a pregnancy complication that endangers both the mother and fetus, so early detection is necessary to prevent serious complications. This study employs mixed methods which combines quantitative and qualitative approaches to design a preeclampsia risk prediction system for pregnant women. The system utilizes four machine learning algorithms: Logistic Regression, Decision Tree, Support Vector Machine (SVM), and Random Forest. We conducted the evaluation process by using a Multi-Method Explainable AI (MM-XAI) approach with Shapley Additive Explanations (SHAP), Local Interpretable Model-agnostic Explanations (LIME), and Permutation Feature Importance (PFI) to enhance the transparency and ease of interpretation of the results. Data were obtained from the Anak Air Community Health Center in the Koto Tangah district of Padang City. Clinical variables included systolic and diastolic blood pressure, blood sugar, body temperature, heart rate, age, and urine protein. The results showed that Random Forest and SVM achieved the highest accuracy at 78%, with consistent predictions across all risk categories. MM-XAI emphasized blood pressure and blood sugar as the dominant features which influenced preeclampsia risk prediction. MM-XAI achieved high accuracy and made it easier for healthcare professionals to understand the determining factors of the prediction. This supports quick, accurate, and accountable medical decision-making.
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References
1. Virtual care clinics [Internet]. Healthdirect.gov.au. Healthdirect Australia; 2024. Available from: https://www.healthdirect.gov.au/virtual-care-clinics.
2. Mahtta D, Daher M, Lee MT, Sayani S, Shishehbor M, Virani SS. Promise and Perils of Telehealth in the Current Era. Current Cardiology Reports. 2021 Jul 16;23(9):1–6.
3. Herzer KR, Pronovost PJ. Ensuring Quality in the Era of Virtual Care. JAMA. 2021 Feb 2;325(5):429.
4. Al Baalharith IM, Aboshaiqah AE. A Delphi study on identifying competencies in virtual healthcare for healthcare professionals. Healthcare. 2024;12(7):1-10.
5. Anthony B. Use of Telemedicine and Virtual Care for Remote Treatment in Response to COVID-19 Pandemic. Journal of Medical Systems. 2020 Jun 15;44(7):1–9.
6. Scott J, Yellowlees P, Becker DF, Chen C. Virtual Care and Mental Health: Dismantling Silos to Strengthen Care Delivery. Telemedicine Reports [Internet]. 2023;4(1):174–9. Available from: https://pubmed.ncbi.nlm.nih.gov/37484480/.
7. Centers for Disease Control and Prevention. About chronic diseases [Internet]. Atlanta (GA): CDC; 2025 [cited 2026 Mar 23]. Available from: https://www.cdc.gov/chronic-disease/about/index.html .
8. Peer N, de Villiers A, Jonathan D, Kalombo C, Kengne AP. Care and management of a double burden of chronic diseases: Experiences of patients and perceptions of their healthcare providers. Francis JM, editor. PLOS ONE. 2020 Jul 16;15(7):e0235710.
9. Cvietusa PJ, Goodrich GK, Steiner JF, Shoup JA, King DK, Ritzwoller DP, et al. Transition to Virtual Asthma Care During the COVID-19 Pandemic: An Observational Study. The Journal of Allergy and Clinical Immunology: In Practice. 2022 Jun;10(6):1569–76.
10. Walter R, Schwab SH, Wilkes M, Yourk D, Zahradka N, Pugmire J, et al. Financial and Clinical Impact of Virtual Care During the COVID-19 Pandemic: Difference-in-Differences Analysis. Journal of Medical Internet Research. 2023 Jan 25;25:e44121–1.
11. Sherifali D, Whitmore C, Naeem F, Melamed OC, Dragonetti R, Kouzoukas E, et al. Technology-Enabled Collaborative Care for Type-2 Diabetes and Mental Health (TECC-D): Findings From a Mixed Methods Feasibility Trial of a Responsive Co-Designed Virtual Health Coaching Intervention. International Journal of Integrated Care [Internet]. 2024 Feb 16;24:12–2. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870944/.
12. Nerpin E, Toft E, Fischier J, Lindholm-Olinder A, Leksell J. A virtual clinic for the management of diabetes-type 1: study protocol for a randomised wait-list controlled clinical trial. BMC Endocrine Disorders. 2020 Sep 5;20(1).
13. Boipelo Tselapedi-Sekeitto, Rocha T, Sowerby LJ, Rotenberg B, Ameen Biadsee. Telemedicine as an environmental ally - The social, financial, and environmental impact of virtual care in the otolaryngology clinic. American Journal of Otolaryngology. 2023 Mar 1;44(2):103791–1.
14. Wali S, Guessi Margarido M, Shah A, Ware P, McDonald M, O’Sullivan M, et al. Expanding Telemonitoring in a Virtual World: A Case Study of the Expansion of a Heart Failure Telemonitoring Program During the COVID-19 Pandemic. Journal of Medical Internet Research. 2021 Jan 22;23(1):e26165.
15. Stamenova V, Chu C, Pang A, Fang J, Shakeri A, Cram P, et al. Virtual care use during the COVID-19 pandemic and its impact on healthcare utilization in patients with chronic disease: A population-based repeated cross-sectional study. Orueta JF, editor. PLOS ONE. 2022 Apr 25;17(4):e0267218.
16. Zhao B, Zhang L, Ji P, Lin J, Han J, Li J, et al. Bridging “Office-Based Care” With the “Virtual Practice Care Model”: Evolving Care for Chronic Kidney Disease Patients in the COVID-19 Pandemic—And Beyond. Frontiers in Medicine. 2020 Nov 9;7.
17. van der Lande ACMH, Treskes RW, Beeres SLMA, Schalij MJ. Continuum of Care: Positioning of the Virtual Hospital. Frontiers in Cardiovascular Medicine [Internet]. 2021 [cited 2022 Oct 25];8:779075. Available from: https://pubmed.ncbi.nlm.nih.gov/35369043/
18. Carter HE, Wallis S, McGowan K, Graves N, Pitt R, Coffey S, et al. Economic evaluation of an integrated virtual care programme for people with chronic illness who are frequent users of health services in Australia. BMJ open [Internet]. 2023 Apr 5;13(4):e066016. Available from: https://pubmed.ncbi.nlm.nih.gov/37019493/.
19. Lovo S, Imeah B, Sari N, O’Connell ME, Milosavljevic S, Angarita-Fonseca A, et al. Effectiveness of an interprofessional assessment and management approach for people with chronic low back disorders delivered via virtual care: A randomized controlled trial pilot intervention. Digital health [Internet]. 2024 May;10:20552076241260569. Available from: https://pubmed.ncbi.nlm.nih.gov/38846367/
20. Bhatia RS, Chu C, Pang A, Tadrous M, Stamenova V, Cram P. Virtual care use before and during the COVID-19 pandemic: a repeated cross-sectional study. CMAJ Open. 2021 Jan;9(1):E107–14.
21. Fritz BA. Virtual Care in Nephrology: An In-Depth Retrospective Analysis of Outcomes Using the Reset Kidney Health Model. Journal of Clinical Medicine [Internet]. 2023 Dec 22 [cited 2024 Feb 27];13(1):66–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779835/.
22. Singer A, Kosowan L, LaBine L, Shenoda D, Katz A, Abrams EM, et al. Characterizing the use of virtual care in primary care settings during the COVID-19 pandemic: a retrospective cohort study. BMC Primary Care. 2022 Dec 10;23(1).
23. Javier SJ, Carey EP, Gunzburger E, Chen HYP, Zeliadt SB, Williams EC, et al. Pain Care Disparities and the Use of Virtual Care Among Racial-Ethnic Minority Groups During COVID-19. Journal of General Internal Medicine. 2024 Jan 22;39(S1):68–78.
24. Ferguson JM, Jacobs J, Yefimova M, Greene L, Heyworth L, Zulman DM. Virtual care expansion in the Veterans Health Administration during the COVID-19 pandemic: clinical services and patient characteristics associated with utilization. J Am Med Inform Assoc. 2021;28(3):453–62.
25. Modica C, Lewis J, Bay R. Advancing Virtual at-Home Care for Community Health Center Patients Using Patient Self-Care Tools, Technology, and Education. Journal of multidisciplinary healthcare. 2024 Feb 1;Volume 17:521–31.
26. Pham Q, Hearn J, Bender JL, Berlin A, Brown I, Bryant-Lukosius D, et al. Virtual care for prostate cancer survivorship: protocol for an evaluation of a nurse-led algorithm-enhanced virtual clinic implemented at five cancer centres across Canada. BMJ Open. 2021 Apr 1;11(4):e045806–6.
27. Katz I, Lane C, Pirabhahar S, Williamson P, Kelly J, Preece R, et al. Integrated virtual medical consultations versus traditional clinic care in a public and a private outpatient service. Integrated Healthcare Journal. 2022 Nov;4(1).
28. Glovacz JW, Betts SG, Cross S, Powell J. Pharmacists’ impact on quality and financial metrics utilizing virtual care platforms during the coronavirus pandemic. American Journal of Health-System Pharmacy. 2022 Feb 8;.
29. Quinn KL, Stukel TA, Detsky A, Chung H, Anwar MR, Bhatia S, et al. Use of virtual care near the end of life before and during the COVID-19 pandemic: A population-based cohort study. PLoS ONE. 2025 Jan 8;20(1):e0313766–6.
30. Killackey T, Noel M, Birnie KA, Choinière M, Pagé MG, Dassieu L, et al. COVID-19 Pandemic Impact and Response in Canadian Pediatric Chronic Pain Care: A National Survey of Medical Directors and Pain Professionals. Canadian Journal of Pain. 2021 Jan 1;5(1):139–50.
31. Velázquez-Jurado H, Pérez-Peralta L, Valle-Nava D, Reynoso-Noverón N, Hernández-Jiménez S, Arcila-Martínez D, et al. Virtual care in patients with type 2 diabetes during COVID-19. Rev Med Inst Mex Seguro Soc. 2024;62(2):1–8.
32. Akhter R, Stukel TA, Chung H, Bell CM, Detsky AS, Downar J, et al. Comparison of physician-delivered models of virtual and home-based in-person care for adults in the last 90 days of life with cancer and terminal noncancer illness during the COVID-19 pandemic. PloS one. 2024;19(11):e0301813.
33. Polanco D, González J, Gracia-Lavedan E, Pinilla L, Plana R, Molina M, et al. Multidisciplinary virtual management of pulmonary nodules. Pulmonology. 2024 May;30(3):239–46.
34. Shear D, Harrison LE, O’Brien S, Khazendar Z, Lyons S, Morgan JJ, et al. Rapid Transition to Virtual Assessment and Treatment in an Interdisciplinary Randomized Clinical Trial for Youth With Chronic Pain: Adaptations and Implications for Future Trials. The Clinical Journal of Pain [Internet]. 2022 Jul 1;38(7):459–69. Available from: https://pubmed.ncbi.nlm.nih.gov/35686576/.
35. Uscher-Pines L, Thompson J, Taylor P, Dean K, Yuan T, Tong I, et al. Where Virtual Care Was Already a Reality: Experiences of a Nationwide Telehealth Service Provider During the COVID-19 Pandemic. Journal of Medical Internet Research. 2020 Dec 15;22(12):e22727.
36. Tzeng YH, Yin WH, Lin KC, Wei J, Liou HR, Sung HJ, et al. Factors Associated With the Utilization of Outpatient Virtual Clinics: Retrospective Observational Study Using Multilevel Analysis. Journal of Medical Internet Research [Internet]. 2022 Aug 12 [cited 2023 Apr 5];24(8):e40288. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377537/#__ffn_sectitle
37. Gray C, Ambady L, Chao S, Smith W, Yoon J. Virtual management of chronic conditions during the COVID-19 pandemic: insights from primary care providers and clinical pharmacists. Mil Med. 2023;188(7–8):e2615–e2620.
38. Chan-Nguyen S, Ritsma B, Nguyen L, Srivastava S, Shukla G, Appireddy R. Virtual Care Access and Health Equity during the COVID-19 Pandemic, a qualitative study of patients with chronic diseases from Canada. DIGITAL HEALTH. 2022 Jan;8:205520762210744.
39. Bevilacqua M, Melnyk Y, Chiu H, Williams J, Watson P, Lee B, et al. Patient and clinician experiences with the combination of virtual and in-person chronic kidney disease care since the COVID-19 pandemic. Can J Kidney Health Dis. 2023;10:20543581231107255.
40. Birnie KA, Killackey T, Backlin G, Gavin F, Harris CR, Jordán I, et al. Ensuring Equity and Inclusion in Virtual Care Best Practices for Diverse Populations of Youth with Chronic Pain. Healthcare quarterly. 2022 Apr 15;24(SP):25–30.
41. Zhang X, McJoynt T, Furst JW, Myers JF. Establishing a Patient-Centered Virtual Care Model Across the Continuum of Care. Journal of Primary Care & Community Health. 2022 Jan;13:215013192210888.
42. Zickuhr L, McCarthy C, Nolan-Thomas E, Westrich-Robertson T, Baker EA, Hanson JL. Shared decision-making during virtual care regarding rheumatologic and chronic conditions: qualitative study of benefits, pitfalls, and optimization. ACR Open Rheumatol. 2024;6(1):32–42.
43. Victoria Borg Debono, Neumark S, Buckley N, Zacharias R, Hapidou EG, Anthonypillai J, et al. Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations. Pain Research & Management [Internet]. 2023 Apr 3 [cited 2023 Aug 21];2023:1–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085656/.
44. Pham Q, El-Dassouki N, Lohani R, Jebanesan A, Young K. The Future of Virtual Care for Older Ethnic Adults Beyond the COVID-19 Pandemic. Journal of Medical Internet Research. 2022 Jan 7;24(1):e29876.
45. Karishini Ramamoorthi, Liu R, Fujioka J, Rathod P, Rosart J, Desveaux L, et al. Navigating Virtual Care Services in Ontario Urban Hospitals, Using Patient Journey Mapping. Journal of Patient Experience. 2023 Jan 1;10.
46. D’Alessandro LN, Brown SC, Campbell F, Ruskin D, Mesaroli G, Makkar M, et al. Rapid mobilization of a virtual pediatric chronic pain clinic in Canada during the COVID-19 pandemic. Canadian Journal of Pain. 2020 Jan 1;4(1):162–7.
47. Verweel L, Packham T, Goldstein R, Brooks D, MacKay C. Implementation of virtual pulmonary rehabilitation during the COVID-19 pandemic: Experiences and perceptions of patients and healthcare providers. Respiratory Medicine. 2024 Apr;225:107588.
48. Bevilacqua M, Chiu H, Melnyk Y, Williams J, Chohan R, Wei J, et al. Protocol for a Multistage Mixed-Methods Evaluation of Multidisciplinary Chronic Kidney Disease Care Quality Following Integration of Virtual and In-Person Care During the COVID-19 Pandemic. Canadian Journal of Kidney Health and Disease. 2022 Jan;9:205435812211031.
49. Nayyar D, Pendrith C, Kishimoto V, Chu C, Fujioka J, Rios P, et al. Quality of virtual care for ambulatory care sensitive conditions: Patient and provider experiences. International Journal of Medical Informatics. 2022 Sep;165:104812.
50. Smithson R, Roche E, Wicker C. Virtual models of chronic disease management: lessons from the experiences of virtual care during the COVID-19 response. Australian Health Review. 2021;
51. Mukhida K, Stewart J, Mehrpooya R, Fraser J. Virtual care for patients with chronic pain and addictions during the COVID-19 pandemic. Canadian Journal of Pain. 2020 Jan 1;4(1):179–80.
52. Pu D, Palmer V, Greenstock L, Pigott C, Peeters A, Sanci L, et al. Identifying Public Healthcare Priorities in Virtual Care for Older Adults: A Participatory Research Study. International Journal of Environmental Research and Public Health [Internet]. 2023 Jan 1 [cited 2023 May 6];20(5):4015. Available from: https://www.mdpi.com/1660-4601/20/5/4015.
53. Barakat‐Johnson M, Kita B, Jones A, Burger M, Airey D, Stephenson J, et al. The viability and acceptability of a Virtual Wound Care Command Centre in Australia. International Wound Journal. 2022 May 24;19(7).
54. Peprah P, Osman S, Mitchell R, Chauhan A, Ramya Walsan, Sina M, et al. Outpatient Virtual Care Among People Living With and Beyond Cancer From Culturally and Linguistically Diverse Backgrounds in Australia: A Protocol for a Realist Evaluation. Health Expectations. 2025 Mar 18;28(2).
55. McConnell M, Kumar P, Rashmi Mullur. The Virtual Visit: A Telehealth Curriculum for Internal Medicine Residents Featuring a Virtual Physical Examination. Journal of Graduate Medical Education. 2023 Oct 1;15(5):582–6.
56. Birnie KA, Pavlova M, Neville A, Noel M, Jordan I, Jordan E, et al. Rapid Evidence and Gap Map of virtual care solutions across a stepped care continuum for youth with chronic pain and their families in response to the COVID-19 pandemic. Pain. 2021 May 28;162(11):2658–68.
57. Buyting R, Melville S, Chatur H, White CW, Légaré JF, Lutchmedial S, et al. Virtual Care With Digital Technologies for Rural Canadians Living With Cardiovascular Disease. CJC Open [Internet]. 2022 Feb 1 [cited 2022 Mar 19];4(2):133–47. Available from: https://www.sciencedirect.com/science/article/pii/S2589790X21002699.
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Copyright (c) 2026 Sari Puspita, S.Si, M.Si, Gusrino Yanto, S.Kom, M.Kom, Rifa Turaina, S.Kom, M.Kom, Nency Extise Putri, S.Kom, M.Kom

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